[HTML][HTML] Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1
SA Oak, YW Zhou, HW Jarrett - Journal of Biological Chemistry, 2003 - ASBMB
The dystrophin glycoprotein complex has been proposed to be involved in signal
transduction. Here we have shown that laminin binding causes syntrophin to recruit Rac1
from the rabbit skeletal muscle. Laminin-Sepharose and syntrophin-Sepharose bind a
protein complex containing Rac1 from the muscle membranes. The presence of heparin,
which inhibits laminin interactions, prevents recruitment of Rac1. The dystrophin
glycoprotein complex recruits Rac1 via syntrophin through a Grb2· Sos1 complex. A …
transduction. Here we have shown that laminin binding causes syntrophin to recruit Rac1
from the rabbit skeletal muscle. Laminin-Sepharose and syntrophin-Sepharose bind a
protein complex containing Rac1 from the muscle membranes. The presence of heparin,
which inhibits laminin interactions, prevents recruitment of Rac1. The dystrophin
glycoprotein complex recruits Rac1 via syntrophin through a Grb2· Sos1 complex. A …