[HTML][HTML] Matrix metalloproteinase-2 expression by vascular smooth muscle cells is mediated by both stimulatory and inhibitory signals in response to growth factors
GM Risinger, TS Hunt, DL Updike, EC Bullen… - Journal of biological …, 2006 - ASBMB
In response to growth factors, vascular smooth muscle cells (VSMCs) undergo a phenotypic
modulation from a contractile, non-proliferative state to an activated, migratory state. This
transition is characterized by changes in their gene expression profile, particularly by a
significant down-regulation of contractile proteins. Platelet-derived growth factor (PDGF)-BB
has long been known to initiate VSMC de-differentiation and mitogenesis. Insulin-like growth
factor (IGF)-I, on the other hand, has differing effects depending on the model studied. Here …
modulation from a contractile, non-proliferative state to an activated, migratory state. This
transition is characterized by changes in their gene expression profile, particularly by a
significant down-regulation of contractile proteins. Platelet-derived growth factor (PDGF)-BB
has long been known to initiate VSMC de-differentiation and mitogenesis. Insulin-like growth
factor (IGF)-I, on the other hand, has differing effects depending on the model studied. Here …