[CITATION][C] Inhibition of IGF-I and b-FGF stimulated growth of human retinal endothelial cells by the somatostatin analogue, octreotide: a potential treatment for ocular …
MB Grant, S Caballero, WJ Millard - Regulatory peptides, 1993 - Elsevier
Neovascularization requires the appropriate balance between proteinases and proteinase
inhibitors. While it is appreciated that extracellular matrix invasion and capillary lumen
formation are inhibited by an excess of proteinase inhibitors, excessive proteolysis is also
incompatible with normal capillary morphogenesis [1]. Regulators ofneovascularization
include the plasminogen activators (PAs), tissue-type (t-PA) and urokinase-type (u-PA).
These convert plasminogen to the serine proteinase plasmin which, in turn, causes …
inhibitors. While it is appreciated that extracellular matrix invasion and capillary lumen
formation are inhibited by an excess of proteinase inhibitors, excessive proteolysis is also
incompatible with normal capillary morphogenesis [1]. Regulators ofneovascularization
include the plasminogen activators (PAs), tissue-type (t-PA) and urokinase-type (u-PA).
These convert plasminogen to the serine proteinase plasmin which, in turn, causes …