Cachectin and tumour necrosis factor as two sides of the same biological coin
B Beutler, A Cerami - Nature, 1986 - nature.com
B Beutler, A Cerami
Nature, 1986•nature.comIn response to invasive stimuli, macrophages secrete cachectin, a multipotent protein.
Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a
lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new
view of its therapeutic potential.
Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a
lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new
view of its therapeutic potential.
Abstract
In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.
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