Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression
A Mantovani, P Allavena, A Sica - European journal of cancer, 2004 - Elsevier
A Mantovani, P Allavena, A Sica
European journal of cancer, 2004•ElsevierMacrophages are versatile, plastic cells which respond to micro-environmental signals with
distinct functional programmes. In the tumour microenvironment, tumour-associated
macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue
remodelling and repair. As polarised type II macrophages, TAM are a key component of the
inflammatory circuits that promote tumour progression.
distinct functional programmes. In the tumour microenvironment, tumour-associated
macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue
remodelling and repair. As polarised type II macrophages, TAM are a key component of the
inflammatory circuits that promote tumour progression.
Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression.
Elsevier