Implications of normal brain development for the pathogenesis of schizophrenia
DR Weinberger - Archives of general psychiatry, 1987 - jamanetwork.com
• Recent research on schizophrenia has demonstrated that in this disorder the brain is not,
strictly speaking, normal. The findings suggest that nonspecific histopathology exists in the
limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in
development, and that the causative process is inactive long before the diagnosis is made. If
these findings are valid and not epiphenomena, then the pathogenesis of schizophrenia
does not appear to fit either traditional metabolic, posttraumatic, or neurodegenerative …
strictly speaking, normal. The findings suggest that nonspecific histopathology exists in the
limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in
development, and that the causative process is inactive long before the diagnosis is made. If
these findings are valid and not epiphenomena, then the pathogenesis of schizophrenia
does not appear to fit either traditional metabolic, posttraumatic, or neurodegenerative …