A new antifungal antibiotic, trichostatin

N Tsuji, M Kobayashi, K Nagashima… - The Journal of …, 1976 - jstage.jst.go.jp
N Tsuji, M Kobayashi, K Nagashima, Y Wakisaka, K Koizumi
The Journal of antibiotics, 1976jstage.jst.go.jp
> 50 0.2 0.39 0.39 1.56 1.56 in SABOURAUD glucose agar medium* 28 C 2 days.** 28 C 7
days. the spectrum lacks fine structure. The NMR spectrum of trichostatin B, unexpectedly,
does not show any proton signals. Therefore, it was assumed that trichostatin B should
include a paramagnetic metal presumably an iron atom, in its molecule. This fact in
combination with the acidic nature of trichostatin A led to the assumption that trichostatin
should have a hydroxamic acid function. As expected, the treatment of trichostatin A with …
> 50 0.2 0.39 0.39 1.56 1.56 in SABOURAUD glucose agar medium* 28 C 2 days.** 28 C 7 days. the spectrum lacks fine structure. The NMR spectrum of trichostatin B, unexpectedly, does not show any proton signals. Therefore, it was assumed that trichostatin B should include a paramagnetic metal presumably an iron atom, in its molecule. This fact in combination with the acidic nature of trichostatin A led to the assumption that trichostatin should have a hydroxamic acid function. As expected, the treatment of trichostatin A with ferric chloride in chloroform solution gave a red solution and the IR spectrum of the product was identical with that of trichostatin
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