[HTML][HTML] p73 independent of c-Myc represses transcription of platelet-derived growth factor β-receptor through interaction with NF-Y
A Hackzell, H Uramoto, H Izumi, K Kohno… - Journal of Biological …, 2002 - ASBMB
We recently reported that c-Myc represses the transcription of platelet-derived growth factor
(PDGF) β-receptor (Izumi, H., Molander, C., Penn, LZ, Ishisaki, A., Kohno, K., and Funa,
K.(2001) J. Cell Sci. 114, 1533–1544). We demonstrate here that the p53 family protein
p73α represses PDGF β-receptor transcription essentially by the same mechanism. p73α but
not p73β or p53 represses the transcription in concordance with its ability to bind NF-YC and
NF-YB. None of other p73 isoforms (ie p73β, p73γ, p73ε), C-terminal deletion mutants of …
(PDGF) β-receptor (Izumi, H., Molander, C., Penn, LZ, Ishisaki, A., Kohno, K., and Funa,
K.(2001) J. Cell Sci. 114, 1533–1544). We demonstrate here that the p53 family protein
p73α represses PDGF β-receptor transcription essentially by the same mechanism. p73α but
not p73β or p53 represses the transcription in concordance with its ability to bind NF-YC and
NF-YB. None of other p73 isoforms (ie p73β, p73γ, p73ε), C-terminal deletion mutants of …