[HTML][HTML] Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice
Scavenger receptor BI (SR-BI) is a multi-ligand lipoprotein receptor that mediates selective
lipid uptake from HDL, and plays a central role in hepatic HDL metabolism. In this report, we
investigated the extent to which SR-BI selective lipid uptake contributes to LDL metabolism.
As has been reported for human LDL, mouse SR-BI expressed in transfected cells mediated
selective lipid uptake from mouse LDL. However, LDL-cholesteryl oleoyl ester (CE) transfer
relative to LDL-CE bound to the cell surface (fractional transfer) was∼ 18-fold lower …
lipid uptake from HDL, and plays a central role in hepatic HDL metabolism. In this report, we
investigated the extent to which SR-BI selective lipid uptake contributes to LDL metabolism.
As has been reported for human LDL, mouse SR-BI expressed in transfected cells mediated
selective lipid uptake from mouse LDL. However, LDL-cholesteryl oleoyl ester (CE) transfer
relative to LDL-CE bound to the cell surface (fractional transfer) was∼ 18-fold lower …