[HTML][HTML] A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly

JD Curb, RD Abbott, BL Rodriguez, K Masaki… - Journal of Lipid …, 2004 - ASBMB
High density lipoprotein cholesterol (HDL-C) levels are inversely associated with the
incidence of coronary heart disease (CHD) in middle-aged individuals; in the elderly, the
association is less clear. Genetic factors, including variations in the cholesteryl ester transfer
protein (CETP) gene, play a role in determining HDL-C levels. Controversy remains about
whether CETP deficiency and the resultant rise in HDL-C are antiatherogenic, or whether
CETP has the opposite effect due to its role in reverse cholesterol transport. In a seven-year …