[HTML][HTML] A new synthetic class A amphipathic peptide analogue protects mice from diet-induced atherosclerosis

DW Garber, G Datta, M Chaddha… - Journal of lipid …, 2001 - ASBMB
Several synthetic class A peptide analogues have been shown to mimic many of the
properties of human apo AI in vitro. A new peptide [acetyl-(AspTrpLeuLysAlaPheTyrAspLysValPheGlu…
)-NH 2; 5F], with increased amphipathicity, was administered by intraperitoneal injection, 20
μg/day for 16 weeks, to C57BL/6J mice fed an atherogenic diet. Mouse apo AI (MoA-I)(50
μg/day) or phosphate-buffered saline (PBS) injections were given to other mice as controls.
Total plasma cholesterol levels and lipoprotein profiles were not significantly different …