Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome
Y Imai, J Parodo, O Kajikawa, M de Perrot, S Fischer… - Jama, 2003 - jamanetwork.com
ContextRecent clinical trials have demonstrated a decrease in multiple organ dysfunction
syndrome (MODS) and mortality in patients with acute respiratory distress syndrome (ARDS)
treated with a protective ventilatory strategy. ObjectiveTo examine the hypothesis that an
injurious ventilatory strategy may lead to end-organ epithelial cell apoptosis and organ
dysfunction. Design and SettingIn vivo animals: 24 rabbits with acid-aspiration lung injury
were ventilated with injurious or noninjurious ventilatory strategies. In vitro: rabbit epithelial …
syndrome (MODS) and mortality in patients with acute respiratory distress syndrome (ARDS)
treated with a protective ventilatory strategy. ObjectiveTo examine the hypothesis that an
injurious ventilatory strategy may lead to end-organ epithelial cell apoptosis and organ
dysfunction. Design and SettingIn vivo animals: 24 rabbits with acid-aspiration lung injury
were ventilated with injurious or noninjurious ventilatory strategies. In vitro: rabbit epithelial …