The immunoregulatory role of IDO-producing human dendritic cells revisited
P Terness, JJ Chuang, G Opelz - Trends in immunology, 2006 - cell.com
P Terness, JJ Chuang, G Opelz
Trends in immunology, 2006•cell.comFollowing the finding that indoleamine 2, 3-dioxygenase (IDO), an enzyme expressed in the
placenta, prevents rejection of allogeneic fetuses in mice, many studies have focused on the
role of IDO in the regulation of the immune response. Most arguments for an
immunoregulatory role of IDO in vivo are based on observations in mice. Here, we critically
examine the arguments for and against a function of IDO-expressing human dendritic cells
(DCs) and conclude that proof for an immunoregulatory role in vivo is still lacking.
placenta, prevents rejection of allogeneic fetuses in mice, many studies have focused on the
role of IDO in the regulation of the immune response. Most arguments for an
immunoregulatory role of IDO in vivo are based on observations in mice. Here, we critically
examine the arguments for and against a function of IDO-expressing human dendritic cells
(DCs) and conclude that proof for an immunoregulatory role in vivo is still lacking.
Following the finding that indoleamine 2,3-dioxygenase (IDO), an enzyme expressed in the placenta, prevents rejection of allogeneic fetuses in mice, many studies have focused on the role of IDO in the regulation of the immune response. Most arguments for an immunoregulatory role of IDO in vivo are based on observations in mice. Here, we critically examine the arguments for and against a function of IDO-expressing human dendritic cells (DCs) and conclude that proof for an immunoregulatory role in vivo is still lacking.
cell.com