PPARγ-agonist rosiglitazone increases number and migratory activity of cultured endothelial progenitor cells
F Pistrosch, K Herbrig, U Oelschlaegel, S Richter… - Atherosclerosis, 2005 - Elsevier
OBJECTIVE:: Endothelial progenitor cells (EPC) are involved in the process of endothelial
maintenance and angiogenesis and might be related to endothelial function. EPC function
was shown to be impaired in type 2 diabetic patients. Since endothelial dysfunction of type 2
diabetic patients can be ameliorated by treatment with thiazolidinediones we asked whether
this treatment might also influence number and function of EPC. METHODS AND
RESULTS:: We investigated 10 recently diagnosed type 2 diabetic patients and 10 age and …
maintenance and angiogenesis and might be related to endothelial function. EPC function
was shown to be impaired in type 2 diabetic patients. Since endothelial dysfunction of type 2
diabetic patients can be ameliorated by treatment with thiazolidinediones we asked whether
this treatment might also influence number and function of EPC. METHODS AND
RESULTS:: We investigated 10 recently diagnosed type 2 diabetic patients and 10 age and …