[HTML][HTML] Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1
JC Mercer, WI DeHaven, JT Smyth, B Wedel… - Journal of Biological …, 2006 - ASBMB
The molecular nature of store-operated Ca 2+-selective channels has remained an enigma,
due largely to the continued inability to convincingly demonstrate Ca 2+-selective store-
operated currents resulting from exogenous expression of known genes. Recent findings
have implicated two proteins, Stim1 and Orai1, as having essential roles in store-operated
Ca 2+ entry across the plasma membrane. However, transient overexpression of these
proteins on their own results in little or no increase in store-operated entry. Here we …
due largely to the continued inability to convincingly demonstrate Ca 2+-selective store-
operated currents resulting from exogenous expression of known genes. Recent findings
have implicated two proteins, Stim1 and Orai1, as having essential roles in store-operated
Ca 2+ entry across the plasma membrane. However, transient overexpression of these
proteins on their own results in little or no increase in store-operated entry. Here we …