[HTML][HTML] Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells

J Soboloff, M Spassova, W Xu, LP He, N Cuesta… - Journal of Biological …, 2005 - ASBMB
The ubiquitously expressed canonical transient receptor potential (TRPC) ion channels are
considered important in Ca 2+ signal generation, but their mechanisms of activation and
roles remain elusive. Whereas most studies have examined overexpressed TRPC channels,
we used molecular, biochemical, and electrophysiological approaches to assess the
expression and function of endogenous TRPC channels in A7r5 smooth muscle cells. Real
time PCR and Western analyses reveal TRPC6 as the only member of the diacylglycerol …