[HTML][HTML] GATA-5 is involved in leukemia inhibitory factor-responsive transcription of the β-myosin heavy chain gene in cardiac myocytes
T Morimoto, K Hasegawa, S Kaburagi, T Kakita… - Journal of biological …, 1999 - ASBMB
Leukemia inhibitory factor is a member of a family of structurally related cytokines sharing
the receptor component gp130. Activation of gp130 by leukemia inhibitory factor is sufficient
to induce myocardial cell hypertrophy accompanied by specific changes in the pattern of
gene expression. However, the molecular mechanisms that link gp130 activation to these
changes have not been clarified. The present study investigated the transcriptional
pathways by which leukemia inhibitory factor activates β-myosin heavy chain expression …
the receptor component gp130. Activation of gp130 by leukemia inhibitory factor is sufficient
to induce myocardial cell hypertrophy accompanied by specific changes in the pattern of
gene expression. However, the molecular mechanisms that link gp130 activation to these
changes have not been clarified. The present study investigated the transcriptional
pathways by which leukemia inhibitory factor activates β-myosin heavy chain expression …