[HTML][HTML] Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy: preservation of systolic function
JA Hill, B Rothermel, KD Yoo, B Cabuay… - Journal of Biological …, 2002 - ASBMB
Calcineurin is a Ca 2+/calmodulin-activated protein phosphatase that transduces
hypertrophic stimuli to regulate transcriptional control of myocyte transformation. It is not
known whether overexpression of MCIP1, a recently described endogenous inhibitor of
calcineurin, impacts the hypertrophic response to pathophysiologically relevant pressure
overload. Further, the functional consequences of calcineurin inhibition by MCIP1 under
conditions of hemodynamic stress are unknown. Transgenic mice expressing a human …
hypertrophic stimuli to regulate transcriptional control of myocyte transformation. It is not
known whether overexpression of MCIP1, a recently described endogenous inhibitor of
calcineurin, impacts the hypertrophic response to pathophysiologically relevant pressure
overload. Further, the functional consequences of calcineurin inhibition by MCIP1 under
conditions of hemodynamic stress are unknown. Transgenic mice expressing a human …