Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H2O positron emission tomography studies

A Drzezga, U Darsow, RD Treede, H Siebner, M Frisch… - Pain, 2001 - Elsevier
The aim of this study was to identify the functional cerebral network involved in the central
processing of itch and to detect analogies and differences to previously identified cerebral
activation patterns triggered by painful noxious stimuli. Repeated positron emission
tomography regional cerebral blood flow (rCBF) measurements using O15-labeled water
were performed in six healthy right-handed male subjects (mean age 32±2 years). Each
subject underwent 12 sequential rCBF measurements. In all subjects a standardized skin …