TRPV3 is a calcium-permeable temperature-sensitive cation channel

H Xu, IS Ramsey, SA Kotecha, MM Moran, JA Chong… - Nature, 2002 - nature.com
H Xu, IS Ramsey, SA Kotecha, MM Moran, JA Chong, D Lawson, P Ge, J Lilly…
Nature, 2002nature.com
Transient receptor potential (TRP) proteins are cation-selective channels that function in
processes as diverse as sensation and vasoregulation. Mammalian TRP channels that are
gated by heat and capsaicin (> 43° C; TRPV1 (ref.)), noxious heat (> 52° C; TRPV2 (ref.)),
and cooling (< 22° C; TRPM8 (refs,)) have been cloned; however, little is known about the
molecular determinants of temperature sensing in the range between∼ 22° C and 40° C.
Here we have identified a member of the vanilloid channel family, human TRPV3 (hTRPV3) …
Abstract
Transient receptor potential (TRP) proteins are cation-selective channels that function in processes as diverse as sensation and vasoregulation. Mammalian TRP channels that are gated by heat and capsaicin (>43 °C; TRPV1 (ref. )), noxious heat (>52 °C; TRPV2 (ref. )), and cooling (< 22 °C; TRPM8 (refs , )) have been cloned; however, little is known about the molecular determinants of temperature sensing in the range between ∼22 °C and 40 °C. Here we have identified a member of the vanilloid channel family, human TRPV3 (hTRPV3) that is expressed in skin, tongue, dorsal root ganglion, trigeminal ganglion, spinal cord and brain. Increasing temperature from 22 °C to 40 °C in mammalian cells transfected with hTRPV3 elevated intracellular calcium by activating a nonselective cationic conductance. As in published recordings from sensory neurons, the current was steeply dependent on temperature, sensitized with repeated heating, and displayed a marked hysteresis on heating and cooling,,,,,. On the basis of these properties, we propose that hTRPV3 is thermosensitive in the physiological range of temperatures between TRPM8 and TRPV1.
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