An animal model of postmenopausal bone loss can be defined as a living animal in which
spontaneous or induced bone loss due to ovarian hormone deficiency can be studied, and
in which the characteristics of the bone loss and its sequalae resemble those found in
postmenopausal women in one or more respects. Although in comparison to humans, the
skeletal mass of rats remains stable for a protracted period during their lifespan, rats can be
ovariectomized to make them sex-hormone deficient, and to stimulate the accelerated loss of …