Mice deficient in the Msx2 gene manifest defects in skull ossification and a marked reduction
in bone formation associated with decreases in osteoblast numbers, thus suggesting that
Msx2 is involved in bone formation. However, the precise role of Msx2 during osteoblast
differentiation is not fully understood. In the present study, we investigated the role of Msx2
in the regulation of osteoblast differentiation in the multipotent mesenchymal cell lines
C3H10T1/2 and C2C12 and in murine primary osteoblasts. Introduction of Msx2 induced …