[HTML][HTML] Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci
M Yamashita, M Ukai-Tadenuma, T Miyamoto… - Journal of Biological …, 2004 - ASBMB
GATA3 expression is essential for type-2 helper T (Th2) cell differentiation. GATA3-mediated
chromatin remodeling at the Th2 cytokine gene loci, including Th2-specific long range
histone hyperacetylation of the interleukin (IL)-13/IL-4 gene loci, occurs in developing Th2
cells. However, little is known about the role of GATA3, if any, in the maintenance of
established remodeled chromatin at the Th2 cytokine gene loci. Here, we established a
Cre/LoxP-based site-specific recombination system in cultured CD4 T cells using a unique …
chromatin remodeling at the Th2 cytokine gene loci, including Th2-specific long range
histone hyperacetylation of the interleukin (IL)-13/IL-4 gene loci, occurs in developing Th2
cells. However, little is known about the role of GATA3, if any, in the maintenance of
established remodeled chromatin at the Th2 cytokine gene loci. Here, we established a
Cre/LoxP-based site-specific recombination system in cultured CD4 T cells using a unique …