Studies on the chemistry of the cord factor of Mycobacterium tuberculosis.
H Noll, H Bloch - Journal of Biological Chemistry, 1955 - cabdirect.org
H Noll, H Bloch
Journal of Biological Chemistry, 1955•cabdirect.orgThe isolation of a toxic glycolipidecord factor'from various strains of virulent tubercle bacilli is
described. It was found to be a characteristic component of the Wax C fraction of the purified
wax." Chemical studies show that cord factor is an ester of mycolic acid having a molecular
weight of about 1570. Alkaline hydrolysis splits the ester linkage, liberating 1 molecule of
mycolic acid and 1 molecule of a non-reducing glucoside. Subsequent acid hydrolysis of the
latter cleaves the glucosidic linkage, yielding glucose and a non-volatile aliphatic fragment …
described. It was found to be a characteristic component of the Wax C fraction of the purified
wax." Chemical studies show that cord factor is an ester of mycolic acid having a molecular
weight of about 1570. Alkaline hydrolysis splits the ester linkage, liberating 1 molecule of
mycolic acid and 1 molecule of a non-reducing glucoside. Subsequent acid hydrolysis of the
latter cleaves the glucosidic linkage, yielding glucose and a non-volatile aliphatic fragment …
Abstract
The isolation of a toxic glycolipidecord factor'from various strains of virulent tubercle bacilli is described. It was found to be a characteristic component of the Wax C fraction of the purified wax.
" Chemical studies show that cord factor is an ester of mycolic acid having a molecular weight of about 1570. Alkaline hydrolysis splits the ester linkage, liberating 1 molecule of mycolic acid and 1 molecule of a non-reducing glucoside. Subsequent acid hydrolysis of the latter cleaves the glucosidic linkage, yielding glucose and a non-volatile aliphatic fragment which has not yet been identified.'Chemical data suggest that the unknown aglycon contains 1 atom of nitrogen which carries a methyl group and cannot be acetylated.".
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