[HTML][HTML] Benzoate X receptors α and β are pharmacologically distinct and do not function as xenobiotic receptors
The Xenopus benzoate nuclear hormone receptors, BXRα and BXRβ, share 82% identity
within their ligand-binding domains and are classified as members of the NR1I2 subfamily
that includes the mammalian steroid and xenobiotic receptor, SXR/PXR. Although alkyl
benzoates have been identified as endogenous ligands, the exact role of the benzoate
receptors in amphibian physiology has not been established. In this report, we show that
BXRα and BXRβ are pharmacologically distinct from each other: BXRα is more promiscuous …
within their ligand-binding domains and are classified as members of the NR1I2 subfamily
that includes the mammalian steroid and xenobiotic receptor, SXR/PXR. Although alkyl
benzoates have been identified as endogenous ligands, the exact role of the benzoate
receptors in amphibian physiology has not been established. In this report, we show that
BXRα and BXRβ are pharmacologically distinct from each other: BXRα is more promiscuous …