[HTML][HTML] 2-Methylene-19-nor-(20S)-1, 25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts
H Yamamoto, NK Shevde, A Warrier, LA Plum… - Journal of Biological …, 2003 - ASBMB
2-Methylene-19-nor-(20S)-1, 25-dihydroxyvitamin D 3 (2MD) is a highly potent analog of 1,
25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3) whose actions are mediated through the vitamin
D receptor (VDR). In this report, we have replicated this increased potency of 2MD in vitro
using osteoblastic cells and explored its underlying molecular mechanism. 2MD stimulates
the expression of several vitamin D-sensitive genes including 25-hydroxyvitamin D 3-24
hydroxylase (Cyp24), osteopontin and receptor activator of NFκB ligand and suppresses …
25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3) whose actions are mediated through the vitamin
D receptor (VDR). In this report, we have replicated this increased potency of 2MD in vitro
using osteoblastic cells and explored its underlying molecular mechanism. 2MD stimulates
the expression of several vitamin D-sensitive genes including 25-hydroxyvitamin D 3-24
hydroxylase (Cyp24), osteopontin and receptor activator of NFκB ligand and suppresses …