[HTML][HTML] Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis
K Kuroda, S Tani, K Tamura, S Minoguchi… - Journal of Biological …, 1999 - ASBMB
Signaling induced by interaction between the receptor Notch and its ligand Delta plays an
important role in cell fate determination in vertebrates as well as invertebrates. Vertebrate
Notch signaling has been investigated using its constitutively active form, ie the truncated
intracellular region which is believed to mimic Notch-Delta signaling by interaction with a
DNA-binding protein RBP-J. However, the molecular mechanism for Notch signaling
triggered by ligand binding, which leads to inhibition of differentiation, is not clear. We have …
important role in cell fate determination in vertebrates as well as invertebrates. Vertebrate
Notch signaling has been investigated using its constitutively active form, ie the truncated
intracellular region which is believed to mimic Notch-Delta signaling by interaction with a
DNA-binding protein RBP-J. However, the molecular mechanism for Notch signaling
triggered by ligand binding, which leads to inhibition of differentiation, is not clear. We have …