The tight junction of the epithelial cell determines the characteristics of paracellular
permeability across epithelium. Recent work points toward the claudin family of tight junction
proteins as leading candidates for the molecular components that regulate paracellular
permeability properties in epithelial tissues. Madin-Darby canine kidney (MDCK) strain I and
II cells are models for the study of tight junctions and based on transepithelial electrical
resistance (TER) contain" tight" and" leaky" tight junctions, respectively. Overexpression …