[HTML][HTML] Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels
NR Coe, MA Simpson, DA Bernlohr - Journal of lipid research, 1999 - ASBMB
The availability of mice containing an adipocyte lipid-binding protein (ALBP/aP2) gene
disruption allowed for a direct examination of the presumed role of lipid-binding proteins in
the mobilization and trafficking of intracellular fatty acids. Total body and epididymal fat pad
weights, as well as adipose cell morphology, were unaltered in male ALBP/aP2 disrupted
mice when compared to their wild-type littermates. Analysis of adipocytes isolated from wild-
type and ALBP/aP2 null mice revealed that a selective 40-and 13-fold increase in the level …
disruption allowed for a direct examination of the presumed role of lipid-binding proteins in
the mobilization and trafficking of intracellular fatty acids. Total body and epididymal fat pad
weights, as well as adipose cell morphology, were unaltered in male ALBP/aP2 disrupted
mice when compared to their wild-type littermates. Analysis of adipocytes isolated from wild-
type and ALBP/aP2 null mice revealed that a selective 40-and 13-fold increase in the level …