Molecular mechanisms of anaphylaxis: lessons from studies with murine models
FD Finkelman, ME Rothenberg, EB Brandt… - Journal of Allergy and …, 2005 - Elsevier
Studies with murine models demonstrate 2 pathways of systemic anaphylaxis: one mediated
by IgE, FcεRI, mast cells, histamine, and platelet-activating factor (PAF), and the other
mediated by IgG, FcγRIII, macrophages, and PAF. The former pathway requires much less
antibody and antigen than the latter. As a result, IgG antibody can block IgE-mediated
anaphylaxis induced by small quantities of antigen without mediating FcγRIII-dependent
anaphylaxis. The IgE pathway is most likely responsible for most human anaphylaxis, which …
by IgE, FcεRI, mast cells, histamine, and platelet-activating factor (PAF), and the other
mediated by IgG, FcγRIII, macrophages, and PAF. The former pathway requires much less
antibody and antigen than the latter. As a result, IgG antibody can block IgE-mediated
anaphylaxis induced by small quantities of antigen without mediating FcγRIII-dependent
anaphylaxis. The IgE pathway is most likely responsible for most human anaphylaxis, which …