[HTML][HTML] Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by β-adrenergic receptor kinase 1: a role in receptor sequestration
SVN Prasad, LS Barak, A Rapacciuolo… - Journal of Biological …, 2001 - ASBMB
Agonist-dependent desensitization of the β-adrenergic receptor requires translocation and
activation of the β-adrenergic receptor kinase1 by liberated Gβγ subunits. Subsequent
internalization of agonist-occupied receptors occurs as a result of the binding of β-arrestin to
the phosphorylated receptor followed by interaction with the AP2 adaptor and clathrin
proteins. Receptor internalization is known to require D-3 phosphoinositides that are
generated by the action of phosphoinositide 3-kinase. Phosphoinositide 3-kinases form a …
activation of the β-adrenergic receptor kinase1 by liberated Gβγ subunits. Subsequent
internalization of agonist-occupied receptors occurs as a result of the binding of β-arrestin to
the phosphorylated receptor followed by interaction with the AP2 adaptor and clathrin
proteins. Receptor internalization is known to require D-3 phosphoinositides that are
generated by the action of phosphoinositide 3-kinase. Phosphoinositide 3-kinases form a …