[HTML][HTML] The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP …
M Huber, L Izzi, P Grondin, C Houde, T Kunath… - Journal of Biological …, 1999 - ASBMB
Biliary glycoprotein (Bgp, C-CAM, or CD66a) is an immunoglobulin-like cell adhesion
molecule and functions as a tumor suppressor protein. We have previously shown that the
Bgp1 isoform responsible for inhibition of colonic, liver, prostate, and breast tumor cell
growth contains within its cytoplasmic domain two tyrosine residues positioned in
immunoreceptortyrosine-based inhibition motif (ITIM) consensus sequences. Moreover, we
determined that these residues, upon phosphorylation, associate with the protein-tyrosine …
molecule and functions as a tumor suppressor protein. We have previously shown that the
Bgp1 isoform responsible for inhibition of colonic, liver, prostate, and breast tumor cell
growth contains within its cytoplasmic domain two tyrosine residues positioned in
immunoreceptortyrosine-based inhibition motif (ITIM) consensus sequences. Moreover, we
determined that these residues, upon phosphorylation, associate with the protein-tyrosine …