[HTML][HTML] Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells
M Rajebhosale, S Greenwood, J Vidugiriene… - Journal of Biological …, 2003 - ASBMB
Neuronal calcium sensor-1 (NCS-1), the mammalian orthologue of frequenin, belongs to a
family of EF-hand-containing Ca 2+ sensors. NCS-1/frequenin has been shown to enhance
synaptic transmission in PC12 cells andDrosophila and Xenopus, respectively. However,
the precise molecular mechanism for the enhancement of exocytosis is largely unknown. In
PC12 cells, NCS-1 potentiated exocytosis evoked by ATP, an agonist to phospholipase C-
linked receptors, but had no effect on depolarization-evoked release. NCS-1 also enhanced …
family of EF-hand-containing Ca 2+ sensors. NCS-1/frequenin has been shown to enhance
synaptic transmission in PC12 cells andDrosophila and Xenopus, respectively. However,
the precise molecular mechanism for the enhancement of exocytosis is largely unknown. In
PC12 cells, NCS-1 potentiated exocytosis evoked by ATP, an agonist to phospholipase C-
linked receptors, but had no effect on depolarization-evoked release. NCS-1 also enhanced …