Alpha-synuclein haplotypes implicated in risk of Parkinson's disease
EK Tan, A Chai, YY Teo, Y Zhao, C Tan, H Shen… - Neurology, 2004 - AAN Enterprises
EK Tan, A Chai, YY Teo, Y Zhao, C Tan, H Shen, VR Chandran, ML Teoh, Y Yih, R Pavanni…
Neurology, 2004•AAN EnterprisesThe authors examined four-and six-loci haplotype constructs (from five single nucleotide
polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with
Parkinson's disease (PD) and controls in an ethnic Chinese population. Logistic regression
analysis demonstrated an association of NACP-Rep1 (p= 0.002) and L478 (p< 0.0001) with
risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific
four-loci and six-loci haplotypes were significantly associated with an increased or …
polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with
Parkinson's disease (PD) and controls in an ethnic Chinese population. Logistic regression
analysis demonstrated an association of NACP-Rep1 (p= 0.002) and L478 (p< 0.0001) with
risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific
four-loci and six-loci haplotypes were significantly associated with an increased or …
The authors examined four- and six-loci haplotype constructs (from five single nucleotide polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with Parkinson’s disease (PD) and controls in an ethnic Chinese population. Logistic regression analysis demonstrated an association of NACP-Rep1 (p = 0.002) and L478 (p < 0.0001) with risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific four-loci and six-loci haplotypes were significantly associated with an increased or decreased risk of PD.
American Academy of Neurology