Association of α‐synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset

GM Hadjigeorgiou, G Xiromerisiou… - … : official journal of the …, 2006 - Wiley Online Library
GM Hadjigeorgiou, G Xiromerisiou, V Gourbali, K Aggelakis, N Scarmeas, A Papadimitriou…
Movement disorders: official journal of the Movement Disorder Society, 2006Wiley Online Library
The α‐synuclein Rep1 polymorphism was studied in patients and controls in an ethnic
Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD;
adjusted odd ratio= 3.25; 95% CI= 1.80–5.87). Survival analyses (Cox proportional hazards
models) were employed to explore the influence of genotypes on age at onset of PD. Age at
onset of carriers of at least one Rep1 allele 2 was earlier (3.6 years) compared to
noncarriers (adjusted hazard ratio= 2.21; 95% CI= 1.58–3.10). Kaplan–Meier analysis also …
Abstract
The α‐synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80–5.87). Survival analyses (Cox proportional hazards models) were employed to explore the influence of genotypes on age at onset of PD. Age at onset of carriers of at least one Rep1 allele 2 was earlier (3.6 years) compared to noncarriers (adjusted hazard ratio = 2.21; 95% CI = 1.58–3.10). Kaplan–Meier analysis also supported a dosage effect of Rep1 allele 2 on age at onset. For Rep1 allele 1, there was neither association with risk of PD nor influence on age at onset. This is the first study showing an influence of Rep1 polymorphism on age at onset of PD. © 2005 Movement Disorder Society
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