Mutations in DJ-1 cause an autosomal recessive, early onset familial form of Parkinson
disease (PD). However, little is presently known about the role of DJ-1 in the more common
sporadic form of PD and in other age-related neurodegenerative diseases, such as
Alzheimer disease (AD). Here we report that DJ-1 is oxidatively damaged in the brains of
patients with idiopathic PD and AD. By using a combination of two-dimensional gel
electrophoresis and mass spectrometry, we have identified 10 different DJ-1 isoforms, of …