The antidiabetic hormone adiponectin circulates in blood as several oligomeric complexes,
and the ratios between them are critical in determining insulin sensitivity. In this study we
investigated the role of testosterone in regulating the oligomeric complex distribution of
adiponectin. Gel filtration analysis revealed that circulating adiponectin existed as the forms
of high molecular weight (HMW), middle molecular weight, and low molecular weight
complexes in both human and mice. The concentration of HMW adiponectin in female was …