[HTML][HTML] Glucose suppresses superoxide generation in metabolically responsive pancreatic β cells
GA Martens, Y Cai, S Hinke, G Stangé… - Journal of biological …, 2005 - ASBMB
High rates of glucose metabolism and mitochondrial electron transport have been
associated with increased mitochondrial production of reactive oxygen species (ROS). This
mechanism was also proposed as a possible cause for dysfunction and death of pancreatic
β cells exposed to high glucose levels. We examined whether high rates of glucose
metabolism increase ROS production in purified rat β cells. Glucose up to 20 mm did not
stimulate H 2 O 2 or superoxide production, whereas it dose-dependently increased cellular …
associated with increased mitochondrial production of reactive oxygen species (ROS). This
mechanism was also proposed as a possible cause for dysfunction and death of pancreatic
β cells exposed to high glucose levels. We examined whether high rates of glucose
metabolism increase ROS production in purified rat β cells. Glucose up to 20 mm did not
stimulate H 2 O 2 or superoxide production, whereas it dose-dependently increased cellular …