The pathological sequence for type 2 diabetes is complex and entails many different
elements that act in concert to cause that disease. This review proposes a sequence of
events and how they interact by a careful analysis of the human and animal model literature.
A genetic predisposition must exist, although to date very little is known about specific
genetic defects in this disease. Whether the diabetes phenotype will occur depends on
many environmental factors that share an ability to stress the glucose homeostasis system …