The RAGE axis and endothelial dysfunction: maladaptive roles in the diabetic vasculature and beyond
R Ramasamy, SF Yan, AM Schmidt - Trends in Cardiovascular Medicine, 2005 - Elsevier
Receptor for advanced glycation end product (RAGE) is a member of the immunoglobulin
superfamily of cell surface molecules. The ligand–RAGE axis is emerging as a central
mechanism linked to vascular injury and atherosclerosis in diabetes and in euglycemia. The
repertoire of RAGE ligands, including advanced glycation end products, S100/calgranulins,
high-mobility group box 1, amyloid-β peptide, and Mac-1, transcends RAGE biology from
specifically the science of diabetic complications to central aspects of the inflammatory …
superfamily of cell surface molecules. The ligand–RAGE axis is emerging as a central
mechanism linked to vascular injury and atherosclerosis in diabetes and in euglycemia. The
repertoire of RAGE ligands, including advanced glycation end products, S100/calgranulins,
high-mobility group box 1, amyloid-β peptide, and Mac-1, transcends RAGE biology from
specifically the science of diabetic complications to central aspects of the inflammatory …