Insulin in the cerebrospinal fluid
RU Margolis, N Altszuler - Nature, 1967 - nature.com
RU Margolis, N Altszuler
Nature, 1967•nature.comSTUDIES involving injection of labelled insulin have been interpreted as evidence that
insulin does not pass into brain1, 2 or cerebrospinal fluid (CSF) 3. Neither was any
significant amount of insulin detected in human CSF using the rat adipose tissue bioassay
technique3, 4. We have reinvestigated the question of whether insulin passes the blood-
CSF barrier using the more sensitive and specific radioimmunoassay technique.
insulin does not pass into brain1, 2 or cerebrospinal fluid (CSF) 3. Neither was any
significant amount of insulin detected in human CSF using the rat adipose tissue bioassay
technique3, 4. We have reinvestigated the question of whether insulin passes the blood-
CSF barrier using the more sensitive and specific radioimmunoassay technique.
Abstract
STUDIES involving injection of labelled insulin have been interpreted as evidence that insulin does not pass into brain1,2 or cerebrospinal fluid (CSF)3. Neither was any significant amount of insulin detected in human CSF using the rat adipose tissue bioassay technique3,4. We have reinvestigated the question of whether insulin passes the blood-CSF barrier using the more sensitive and specific radioimmunoassay technique.
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