[HTML][HTML] Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase γ3 R225Q transgenic versus knock-out mice
EC Nilsson, YC Long, S Martinsson, S Glund… - Journal of Biological …, 2006 - ASBMB
AMP-activated protein kinase (AMPK) is an evolutionarily conserved heterotrimer important
for metabolic sensing in all eukaryotes. The muscle-specific isoform of the regulatory γ-
subunit of the kinase, AMPK γ3, has an important role in glucose uptake, glycogen
synthesis, and fat oxidation in white skeletal muscle, as previously demonstrated by
physiological characterization of AMPK γ3 mutant (R225Q) transgenic (TgPrkag3 225Q) and
γ3 knock-out (Prkag3-/-) mice. We determined AMPK γ3-dependent regulation of gene …
for metabolic sensing in all eukaryotes. The muscle-specific isoform of the regulatory γ-
subunit of the kinase, AMPK γ3, has an important role in glucose uptake, glycogen
synthesis, and fat oxidation in white skeletal muscle, as previously demonstrated by
physiological characterization of AMPK γ3 mutant (R225Q) transgenic (TgPrkag3 225Q) and
γ3 knock-out (Prkag3-/-) mice. We determined AMPK γ3-dependent regulation of gene …