[HTML][HTML] Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
H Sano, S Kane, E Sano, CP Mı̂inea, JM Asara… - Journal of Biological …, 2003 - ASBMB
Insulin stimulates the rapid translocation of intracellular glucose transporters of the GLUT4
isotype to the plasma membrane in fat and muscle cells. The connections between known
insulin signaling pathways and the protein machinery of this membrane-trafficking process
have not been fully defined. Recently, we identified a 160-kDa protein in adipocytes,
designated AS160, that is phosphorylated by the insulin-activated kinase Akt. This protein
contains a GTPase-activating domain (GAP) for Rabs, which are small G proteins required …
isotype to the plasma membrane in fat and muscle cells. The connections between known
insulin signaling pathways and the protein machinery of this membrane-trafficking process
have not been fully defined. Recently, we identified a 160-kDa protein in adipocytes,
designated AS160, that is phosphorylated by the insulin-activated kinase Akt. This protein
contains a GTPase-activating domain (GAP) for Rabs, which are small G proteins required …