[HTML][HTML] Rosiglitazone controls fatty acid cycling in human adipose tissue by means of glyceroneogenesis and glycerol phosphorylation
SN Leroyer, J Tordjman, G Chauvet, J Quette… - Journal of Biological …, 2006 - ASBMB
Control of fatty acid homeostasis is crucial to prevent insulin resistance. During fasting, the
plasma fatty acid level depends on triglyceride lipolysis and fatty acid re-esterification within
fat cells. In rodents, Rosiglitazone® controls fatty acid homeostasis by stimulating two
pathways in the adipocytes, glyceroneogenesis and glycerol phosphorylation, that provide
the glycerol 3-phosphate necessary for fatty acid re-esterification. Here, we analyzed the
functionality of both pathways for controlling fatty acid release in subcutaneous adipose …
plasma fatty acid level depends on triglyceride lipolysis and fatty acid re-esterification within
fat cells. In rodents, Rosiglitazone® controls fatty acid homeostasis by stimulating two
pathways in the adipocytes, glyceroneogenesis and glycerol phosphorylation, that provide
the glycerol 3-phosphate necessary for fatty acid re-esterification. Here, we analyzed the
functionality of both pathways for controlling fatty acid release in subcutaneous adipose …