Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

S Sakaguchi - Nature immunology, 2005 - nature.com
Nature immunology, 2005nature.com
Abstract Naturally arising CD25+ CD4+ regulatory T cells actively maintain immunological
self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune
disease. A reduction in their number or function can also elicit tumor immunity, whereas their
antigen-specific population expansion can establish transplantation tolerance. They are
therefore a good target for designing ways to induce or abrogate immunological tolerance to
self and non-self antigens.
Abstract
Naturally arising CD25+CD4+ regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. A reduction in their number or function can also elicit tumor immunity, whereas their antigen-specific population expansion can establish transplantation tolerance. They are therefore a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens.
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