Virulence and vaccine potential of phoP mutants of Salmonella typhimurium
JE Galán, R Curtiss III - Microbial pathogenesis, 1989 - Elsevier
We have constructed Salmonella typhimurium phoP mutants and found them to be avirulent
and able to induce a protective immune response. BALB/c mice survived challenge with
phoP derivatives of the highly virulent S. typhimurium strains SR-11 and SL1344 when
inoculated intraperitoneally and per oral with doses equivalent to 10 4 50% lethal doses (LD
50) of the parent virulent strains. The avirulent mutants were able to establish an infection of
the Peyer's patches of orally infected animals for up to 10 days after inoculation but were …
and able to induce a protective immune response. BALB/c mice survived challenge with
phoP derivatives of the highly virulent S. typhimurium strains SR-11 and SL1344 when
inoculated intraperitoneally and per oral with doses equivalent to 10 4 50% lethal doses (LD
50) of the parent virulent strains. The avirulent mutants were able to establish an infection of
the Peyer's patches of orally infected animals for up to 10 days after inoculation but were …