[HTML][HTML] Phosphorylation of p22 phox is mediated by phospholipase D-dependent and-independent mechanisms: correlation of NADPH oxidase activity and p22 phox …

DS Regier, DG Greene, S Sergeant, AJ Jesaitis… - Journal of Biological …, 2000 - ASBMB
Human neutrophils participate in the host innate immune response, partly mediated by the
multicomponent superoxide-generating enzyme NADPH oxidase. A correlation between
phosphorylation of cytosolic NADPH oxidase components and enzyme activation has been
identified but is not well understood. We previously showed that p22 phox, the small subunit
of the membrane-bound oxidase component flavocytochromeb 558, is an in vitro substrate
for both a phosphatidic acid-activated kinase and conventional protein kinase C isoforms …