Cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase. Transfer of Rac2 and the cytosolic …
J el Benna, JM Ruedi, BM Babior - Journal of Biological Chemistry, 1994 - ASBMB
The respiratory burst oxidase is responsible for O2-production in stimulated neutrophils and
B lymphocytes. Components of this oxidase include cytochrome b558, a membrane-bound
flavohemoprotein; the cytosolic polypeptides p47phox and p67phox; and one or more small
G proteins including Rac1, Rac2, and/or Rap1A. We found that when normal neutrophils
were activated, small percentages of each of the cytosolic proteins p47phox, p67phox, and
Rac2 were transferred to the membrane cytoskeleton. However, Rac2 was not transferred to …
B lymphocytes. Components of this oxidase include cytochrome b558, a membrane-bound
flavohemoprotein; the cytosolic polypeptides p47phox and p67phox; and one or more small
G proteins including Rac1, Rac2, and/or Rap1A. We found that when normal neutrophils
were activated, small percentages of each of the cytosolic proteins p47phox, p67phox, and
Rac2 were transferred to the membrane cytoskeleton. However, Rac2 was not transferred to …