[HTML][HTML] Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the …
The class II histone deacetylases (HDACs) 4, 5, and 7 share a common structural
organization, with a carboxyl-terminal catalytic domain and an amino-terminal extension that
mediates interactions with members of the myocyte enhancer factor-2 (MEF2) family of
transcription factors. Association of these HDACs with MEF2 factors represses transcription
of MEF2 target genes. MEF2-interacting transcription repressor (MITR) shares homology
with the amino-terminal extensions of class II HDACs and also acts as a transcriptional …
organization, with a carboxyl-terminal catalytic domain and an amino-terminal extension that
mediates interactions with members of the myocyte enhancer factor-2 (MEF2) family of
transcription factors. Association of these HDACs with MEF2 factors represses transcription
of MEF2 target genes. MEF2-interacting transcription repressor (MITR) shares homology
with the amino-terminal extensions of class II HDACs and also acts as a transcriptional …