[HTML][HTML] The cardiac-specific nuclear δB isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with …
T Zhang, EN Johnson, Y Gu, MR Morissette… - Journal of Biological …, 2002 - ASBMB
The δ isoform of Ca 2+/calmodulin-dependent protein kinase II (CaMKII) predominates in the
heart. To investigate the role of CaMKII in cardiac function, we made transgenic (TG) mice
that express the nuclear δ B isoform of CaMKII. The expressed CaMKIIδ B transgene was
restricted to the myocardium and highly concentrated in the nucleus. Cardiac hypertrophy
was evidenced by an increased left ventricle to body weight ratio and up-regulation of
embryonic and contractile protein genes including atrial natriuretic factor, β-myosin heavy …
heart. To investigate the role of CaMKII in cardiac function, we made transgenic (TG) mice
that express the nuclear δ B isoform of CaMKII. The expressed CaMKIIδ B transgene was
restricted to the myocardium and highly concentrated in the nucleus. Cardiac hypertrophy
was evidenced by an increased left ventricle to body weight ratio and up-regulation of
embryonic and contractile protein genes including atrial natriuretic factor, β-myosin heavy …